Defective plasma membrane H(+)-ATPase or orthovanadate resistant mutants from Candida albicans, a pathogenic yeast.

@article{Mahanty1990DefectivePM,
  title={Defective plasma membrane H(+)-ATPase or orthovanadate resistant mutants from Candida albicans, a pathogenic yeast.},
  author={Sanjoy K. Mahanty and Praveena Gupta and Utpal Banerjee and Rati Fotedar and Ranjan Prasad},
  journal={Biochemistry international},
  year={1990},
  volume={22 1},
  pages={11-20}
}
Orthovanadate-resistant mutants of diploid yeast Candida albicans were isolated by using two step mutational process. Such mutants had altered plasma membrane H(+)-ATPase activity. Based on the levels of PM-ATPase activity, these mutants could be grouped into two categories; one group included those mutants which did not exhibit reduction in PM-ATPase activity while the other displayed a reduction of upto 40% in enzyme activity. These mutants exhibited a number of distinct phenotypic… CONTINUE READING

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