Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.

@article{Gnarra1997DefectivePV,
  title={Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.},
  author={James R. Gnarra and Jerrold M Ward and Forbes D Porter and Jeffrey R. Wagner and Deborah E. Devor and A. S. Grinberg and M R Emmert-Buck and Heiner Westphal and Richard D. Klausner and W. Marston Linehan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 17},
  pages={
          9102-7
        }
}
Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel-Lindau disease, and somatic VHL inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. The VHL gene was disrupted by targeted homologous recombination in murine embryonic stem cells, and a mouse line containing an inactivated VHL allele was generated. While heterozygous VHL (+/-) mice appeared phenotypically normal, VHL -/- mice died in… CONTINUE READING

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