Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

@article{Li2009DefectivePO,
  title={Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.},
  author={Suzhao Li and Yu Sun and Chien-ping Liang and Edward B Thorp and Seongah Han and Andreas Werner Jehle and Viswanathan Saraswathi and Brian C Pridgen and Jenny E Kanter and Rong Li and Carrie L. Welch and Alyssa H Hasty and Karin E Bornfeldt and Jan L. Breslow and I ra Tabas and Alan Richard Tall},
  journal={Circulation research},
  year={2009},
  volume={105 11},
  pages={1072-82}
}
RATIONALE The complications of atherosclerosis are a major cause of death and disability in type 2 diabetes. Defective clearance of apoptotic cells by macrophages (efferocytosis) is thought to lead to increased necrotic core formation and inflammation in atherosclerotic lesions. OBJECTIVE To determine whether there is defective efferocytosis in a mouse model of obesity and atherosclerosis. METHODS AND RESULTS We quantified efferocytosis in peritoneal macrophages and in atherosclerotic… CONTINUE READING