Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy.

@article{Kedzierska2003DefectivePB,
  title={Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy.},
  author={Katherine Kedzierska and Rita N. Azzam and Philip J. Ellery and Johnson Mak and Anthony Jaworowski and Suzanne M. Crowe},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2003},
  volume={26 2},
  pages={
          247-63
        }
}
Defective immunological function of cells of the macrophage lineage contributes considerably to the pathogenesis of HIV-1 infection. Impairment of phagocytosis of opportunistic pathogens such as Mycobacterium avium complex (MAC), Pneumocystis carinii, Toxoplasma gondii or Candida albicans by peripheral blood monocytes, tissue macrophages and monocyte-derived macrophages following in vivo and in vitro HIV-1 infection is well documented. The development of opportunistic infections due to these… CONTINUE READING

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