Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

@article{Bonora2006DefectiveOP,
  title={Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.},
  author={E. Bonora and A. Porcelli and G. Gasparre and A. Biondi and A. Ghelli and V. Carelli and A. Baracca and G. Tallini and A. Martinuzzi and G. Lenaz and M. Rugolo and G. Romeo},
  journal={Cancer research},
  year={2006},
  volume={66 12},
  pages={
          6087-96
        }
}
Oncocytic tumors are characterized by cells with an aberrant accumulation of mitochondria. To assess mitochondrial function in neoplastic oncocytic cells, we studied the thyroid oncocytic cell line XTC.UC1 and compared it with other thyroid non-oncocytic cell lines. Only XTC.UC1 cells were unable to survive in galactose, a condition forcing cells to rely solely on mitochondria for energy production. The rate of respiration and mitochondrial ATP synthesis driven by complex I substrates was… Expand
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