Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition.

@article{Friedberg2000DefectiveNE,
  title={Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition.},
  author={Errol C. Friedberg and Jeffrey P. Bond and Dennis K. Burns and David L. Cheo and Marc S. Greenblatt and Lisiane B. Meira and Dorit Nahari and Antonio M C Reis},
  journal={Mutation research},
  year={2000},
  volume={459 2},
  pages={99-108}
}
Mice that are genetically engineered are becoming increasingly more powerful tools for understanding the molecular pathology of many human hereditary diseases, especially those that confer an increased predisposition to cancer. We have generated mouse strains defective in the Xpc gene, which is required for nucleotide excision repair (NER) of DNA. Homozygous mutant mice are highly prone to skin cancer following exposure to UVB radiation, and to liver and lung cancer following exposure to the… CONTINUE READING
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