Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase.

@article{Lee2002DefectiveNO,
  title={Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase.},
  author={K M Lee and Hyun-Jeong Kim and Jung Joon Sung and K N Park and Manho Kim},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={2002},
  volume={20 6},
  pages={521-6}
}
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron involvement. Mutations in the human Cu/Zn superoxide dismutase (SOD1) gene are found in some cases of familial ALS. Many studies have reported SOD1 mutation-related neurodegeneration. However, whether or not a mutant SOD1 affects neural development has not been demonstrated. We developed motor neuron-neuroblastoma hybrid cells that expressed a mutant (G93A) or the wild type (WT) SOD1… CONTINUE READING