Defective modulation of angiotensin II-induced renal vasoconstriction in hypertensive rats.

@article{Jackson1994DefectiveMO,
  title={Defective modulation of angiotensin II-induced renal vasoconstriction in hypertensive rats.},
  author={Edwin K Jackson and William A. Herzer},
  journal={Hypertension},
  year={1994},
  volume={23 3},
  pages={329-36}
}
In a previous study we observed that the ability of intravenous infusions of prostaglandin I2 to attenuate vasoconstriction caused by intravenous infusions of angiotensin II was reduced in the renal but not mesenteric vasculature of spontaneously hypertensive rats (SHR). One objective of the current study was to determine whether a renal defect in the angiotensin II/prostaglandin I2 interaction in SHR could be confirmed even when confounding hemodynamic changes induced by intravenous infusions… CONTINUE READING

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