Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors.

@article{Savagner2001DefectiveMA,
  title={Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors.},
  author={Fr{\'e}d{\'e}rique Savagner and Brigitte Franc and Serge Guy{\'e}tant and Patrice Rodien and Pascal Reynier and Yves Malthi{\'e}ry},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 10},
  pages={
          4920-5
        }
}
Oxyphilic tumors (oncocytomas or Hürthle cell tumors) form a rare subgroup of thyroid tumors characterized by cells containing abundant mitochondria. The relationship between the mitochondrial proliferation and the pathogenesis of these tumors is unknown. We have assessed the expression of the mitochondrial ND2 and ND5 (subunits of the nicotinamide adenine dinucleotide dehydrogenase complex) genes and the nuclear UCP2 (uncoupling protein 2) gene in 22 oxyphilic thyroid tumors and matched… 

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