Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

@article{Branch1993DefectiveMB,
  title={Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage},
  author={Pauline Branch and Gabriele Aquilina and Margherita Bignami and P. Karran},
  journal={Nature},
  year={1993},
  volume={362},
  pages={652-654}
}
ACQUIRED resistance to alkylating agents such as N-methyl-N-nitrosourea or N-methyl-N′ -nitro-N-nitrosoguanidine results from the ability to tolerate the potentially cytotoxic methylated base O6-methylguanine (m6-G) in DNA. In the absence of repair by demethylation in situ, m6-G is probably lethal through its inappropriate processing by the cell1. DNA mismatch correction is an attractive candidate for the processing function because although it is replicated, m6-G has no perfect complementary… CONTINUE READING

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