Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats

SEVERAL enzymes are involved in the microbicidal activity of phagocytes1–3. Gluthathione peroxidase (GSHPx) deficiency has been associated with decreased microbicidal ability in leukocytes from two female patients with chronic granulomatous disease, a rare hereditary disorder4. With the discovery that the essential trace element selenium (Se) is an integral… CONTINUE READING