Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells.

@article{Huynh2004DefectiveLE,
  title={Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells.},
  author={Chau V. Huynh and Doris Roth and Diane M Ward and Jerry Kaplan and Norma W Andrews},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 48},
  pages={16795-800}
}
Plasma membrane resealing is a Ca(2+)-dependent process that involves the exocytosis of intracellular vesicles next to the wound site. Recent studies revealed that conventional lysosomes behave as Ca(2+)-regulated secretory compartments and play a central role in membrane resealing. These findings raised the possibility that the complex pathology of lysosomal diseases might also include defects in plasma membrane repair. Here, we investigated the capacity for lysosomal exocytosis and membrane… CONTINUE READING

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