Defective lymphocyte caspase-3 expression in type 1 diabetes mellitus.

@article{Vendrame2005DefectiveLC,
  title={Defective lymphocyte caspase-3 expression in type 1 diabetes mellitus.},
  author={Francesco Vendrame and Carmela Santangelo and Roberta Misasi and Sabrina Dionisi and Chiara Gizzi and Massimo Realacci and Daniele Grassetti and Umberto di Mario and Francesco Dotta},
  journal={European journal of endocrinology},
  year={2005},
  volume={152 1},
  pages={119-25}
}
OBJECTIVE Activation-induced cell death (AICD) is a major mechanism in the regulation of peripheral tolerance and its impairment can determine the development of autoimmunity. In the present study, in order to evaluate the role of caspase-3 in type 1 diabetes mellitus (T1DM) AICD, caspase-3 expression was analyzed in peripheral blood lymphocytes from 37 new onset T1DM patients and from 36 normal control subjects (NC) in resting conditions and after anti-Fas-triggered apoptosis. METHODS… CONTINUE READING
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associated with other autoimmune diseases

  • I Nicoletti, G Migliorati, MC Pagliacci, F Grignani, C Riccardi
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