Defective lentiviral vectors are efficiently trafficked by HIV-1 and inhibit its replication.

@article{Klimatcheva2001DefectiveLV,
  title={Defective lentiviral vectors are efficiently trafficked by HIV-1 and inhibit its replication.},
  author={Ekaterina Klimatcheva and Vicente Planelles and S L Day and F Fulreader and Matthew J. Renda and Joseph D. Rosenblatt},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2001},
  volume={3 6},
  pages={
          928-39
        }
}
Gene therapy against HIV infection should involve vector-mediated delivery of anti-HIV therapeutic genes into T-lymphocytes and macrophages or, alternatively, hematopoietic progenitors. Transduction of mature cells with defective vectors would have limited success because the vector would disappear with cell turnover. However, if a vector could be trafficked by wild-type HIV, initial transduction of a majority of the population would not be required, as the vector would be able to spread. We… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells

  • International journal of medical sciences
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND