Defective laminin 5 processing in cylindroma cells.

  title={Defective laminin 5 processing in cylindroma cells.},
  author={Lucy Tunggal and Juliette Ravaux and Monika Pesch and Hans Smola and Thomas Krieg and Francoise Gaill and Takako Sasaki and Rupert Timpl and Cornelia Mauch and Monique Aumailley},
  journal={The American journal of pathology},
  volume={160 2},
Cylindromas are benign skin tumors occurring as multiple nodules characteristically well circumscribed by an excess of basement membrane-like material. To determine the molecular defects leading to extracellular matrix accumulation, the ultrastructural, immunological, and biochemical properties of cylindroma tissue and isolated cells were analyzed. In cylindromas, hemidesmosomes are reduced in number, heterogeneous and immature compared to the normal dermal-epidermal junction. Expression of the… CONTINUE READING


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