Defective interfering particles with covalently linked [±]RNA induce interferon

@article{Marcus1977DefectiveIP,
  title={Defective interfering particles with covalently linked [±]RNA induce interferon},
  author={Philip I. Marcus and Margaret J. Sekellick},
  journal={Nature},
  year={1977},
  volume={266},
  pages={815-819}
}
Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [−]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [−]RNA DI particles… CONTINUE READING

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