Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat.

@article{Sloniger2005DefectiveIS,
  title={Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat.},
  author={J. Sloniger and V. Saengsirisuwan and Cody J. Diehl and B. Dokken and Narissara Lailerd and A. M. Lemieux and J. Kim and E. Henriksen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 6},
  pages={
          E1074-81
        }
}
Essential hypertension is frequently associated with insulin resistance of skeletal muscle glucose transport, with a potential role of angiotensin II in the pathogenesis of both conditions. The male heterozygous TG(mREN2)27 rat harbors the mouse transgene for renin, exhibits local elevations in angiotensin II, and is an excellent model of both hypertension and insulin resistance. The present study was designed to investigate the potential cellular mechanisms for insulin resistance in this… Expand
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