Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus.

@article{Colomiere2009DefectiveIS,
  title={Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus.},
  author={Michelle Colomiere and Michael J Permezel and Clyde Riley and Gernot Desoye and Martha Lappas},
  journal={European journal of endocrinology},
  year={2009},
  volume={160 4},
  pages={567-78}
}
OBJECTIVE Studies in adipose tissue and skeletal muscle suggest that impaired insulin action is due to defects in the insulin signaling pathway and may play a role in the pathophysiology of insulin resistance associated with gestational diabetes mellitus (GDM) and obesity. The present study tested the hypothesis that endogenous expression levels in the human term placenta of insulin signaling components are altered in placental tissue from GDM women in comparison with normal controls and… CONTINUE READING
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