Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

@article{Xuan2002DefectiveIS,
  title={Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.},
  author={Shouhong Xuan and Tadahiro Kitamura and Jun Nakae and Katerina A Politi and Yoshiaki Kido and Peter E. Fisher and Manrico Morroni and Saverio Cinti and Morris F. White and Pedro L Herrera and Domenico Accili and A. Efstratiadis},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 7},
  pages={1011-9}
}
Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…