Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)

  title={Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)},
  author={Aabida Saferali and Soizik Berlivet and John C. Schimenti and Marisa S Bartolomei and Teruko Taketo and Anna K Naumova},
  journal={Mammalian Genome},
Meiotic silencing of unsynapsed chromatin (MSUC) occurs in the germ cells of translocation carriers and may cause meiotic arrest and infertility. We hypothesized that if bypassing meiotic checkpoints MSUC may cause epigenetic defects in sperm. We investigated the meiotic behavior of the Robertsonian translocation Rb (8.12) in mice. The unsynapsed 8 and 12 trivalent was associated with the XY body during early and mid-pachynema in heterozygous Rb (8.12) carriers, suggesting possible silencing of… CONTINUE READING
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