Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.

@article{Migueles2009DefectiveHI,
  title={Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.},
  author={Stephen A Migueles and Kristin A Weeks and Eric Nou and Amy M Berkley and Julia E. Rood and Christine M. Osborne and Claire W. Hallahan and Nancy A Cogliano-Shutta and Julia A. Metcalf and Mary T McLaughlin and Richard Kwan and Joann M Mican and Richard T. Davey and Mark Connors},
  journal={Journal of virology},
  year={2009},
  volume={83 22},
  pages={11876-89}
}
Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that are not merely modulated by the level of virus but clearly distinguish patients with immune control from those without such control is of paramount importance. Features of the HIV-specific CD8+ T-cell response in antiretroviral-treated patients (designated Rx <50) and untreated patients (long-term nonprogressors [LTNP]) matched for very low HIV RNA levels were comprehensively examined. The proliferative… CONTINUE READING

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