Defective homologous recombination in human cancers.

  title={Defective homologous recombination in human cancers.},
  author={Aiste Cerbinskaite and Arnab Mukhopadhyay and Elizabeth Ruth Plummer and Nicola J Curtin and Richard J Edmondson},
  journal={Cancer treatment reviews},
  volume={38 2},
Homologous recombination (HR) is a process by which DNA double strand breaks are repaired through the alignment of homologous sequences of DNA. Interest continues to increase in HR pathway function due to the development of new therapeutic agents which selectively exploit DNA damage repair pathways. Currently the most promising of these new agents are inhibitors of poly(ADP ribose) polymerase (PARP). The response of cancers known to be deficient in HR, due to BRCA1 or 2 mutations has been… CONTINUE READING

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