Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C.

@article{Huang2007DefectiveHR,
  title={Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C.},
  author={Ying Huang and Jordan J Feld and Ronda K Sapp and Santosh Nanda and Jiing-Huey Lin and Lawrence Mitchell Blatt and Michael W. Fried and K. V. Sreerama Murthy and T. Jake Liang},
  journal={Gastroenterology},
  year={2007},
  volume={132 2},
  pages={733-44}
}
BACKGROUND & AIMS Approximately half of hepatitis C virus (HCV)-infected patients do not respond to current interferon (IFN)-alpha combination therapy. To understand IFN-alpha resistance in vivo, we examined the dynamic responses to both type I and type II IFNs, human IFN (hIFN)-alpha, -gamma, and consensus IFN, in the chimpanzee model. METHODS Naive and HCV-infected chimpanzees were treated with 3 forms of hIFNs in vivo. Quantitative real-time polymerase chain reaction was performed to… CONTINUE READING