Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice.

@article{Dickson1995DefectiveHA,
  title={Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice.},
  author={Marion Dickson and Julie S. Martin and Frances M. Cousins and Ashok Kulkarni and Stefan Karlsson and Rosemary J. Akhurst},
  journal={Development},
  year={1995},
  volume={121 6},
  pages={1845-54}
}
Transforming growth factor beta 1 (TGF beta 1) is shown here to be required for yolk sac haematopoiesis and endothelial differentiation. Mice with a targeted mutation in the TGF beta 1 gene were examined to determine the cause of prenatal lethality, which occurs in 50% of homozygous TGF beta 1 null (TGF beta 1-/-) conceptions. 50% of TGF beta 1-/- and 25% of TGF beta 1-+-) conceptions. 50% of TGF beta 1-/- and 25% of TGF beta 1+/- conceptuses were found to die at around 10.5 dpc. The primary… CONTINUE READING
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