Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.

  title={Defective granulocyte chemotaxis in the Chediak-Higashi syndrome.},
  author={Robert A. Clark and Harold Kimball},
  journal={The Journal of clinical investigation},
  volume={50 12},
In vivo and in vitro studies of granulocyte chemotaxis were performed in three patients with the Chediak-Higashi syndrome. Rebuck skin windows showed a decreased accumulation of leukocytes at an inflammatory site. Studies in Boyden chambers documented a cellular defect in granulocyte chemotaxis. The chemotactic response of Chediak-Higashi cells by this technique averaged approximately 40% of normal and was consistently reduced using several different chemotactic stimuli. This deficit was… CONTINUE READING


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