Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity.

@article{Blumbach2010DefectiveGT,
  title={Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity.},
  author={Katrin Blumbach and Manon C. Zweers and Georg Brunner and Andreas Strobl Karin Teichmann Mike Peters and Markus Schmitz and J Schulz and Alexander Schild and Christopher P. Denton and Takao Sakai and Reinhard F{\"a}ssler and Thomas M. Krieg and Beate Eckes},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 22},
  pages={3872-83}
}
Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK) is a central adapter recruited to integrin β1 tails in focal adhesions mediating the communication between cells and extracellular matrix. Here, we show that fibroblast-restricted inactivation of ILK in mice leads to impaired healing due to a severe reduction in the number of myofibroblasts, whereas inflammatory infiltrate… CONTINUE READING