Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus.

@article{Amiel1987DefectiveGC,
  title={Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus.},
  author={Stephanie A. Amiel and William V Tamborlane and Donald C Simonson and Robert S. Sherwin},
  journal={The New England journal of medicine},
  year={1987},
  volume={316 22},
  pages={1376-83}
}
We infused small doses of insulin (0.3 mU per kilogram of body weight per minute; range, 0.9 to 1.7 U per hour) for three hours into 8 subjects who did not have diabetes, 11 patients with well-controlled diabetes (hemoglobin A1, 7.6 +/- 0.7 percent), and 10 patients with poorly controlled diabetes (hemoglobin A1, 11.5 +/- 1.7 percent) to simulate the mild peripheral hyperinsulinemia observed during insulin treatment. Normoglycemia was established in the patients during the night before study… CONTINUE READING

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