Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy.

@article{Coppo2018DefectiveGE,
  title={Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy.},
  author={Rosanna Coppo and Licia Peruzzi and Elisa Loiacono and Massimilano Bergallo and Alexandra Krutova and Maria Luisa Russo and Enrico Cocchi and Alessandro Amore and Sigrid Lundberg and Dita Maixnerova and V. Tesar and Agnieszka Perkowska-Ptasinska and Magdalena Durlik and Dimitris Goumenos and Miltiadis K. Gerolymos and KRESIMIR Gale{\vs}i{\'c} and Luka Tori{\'c} and Aikaterini Papagianni and Maria Stangou and Malgorzata Mizerska-Wasia Membek and Loreto Gesualdo and Eustacchio Montemurno and Luisa Benozzi and Stefano Cusinato and Tomasz Hryszko and Marian Klinger and Dorota Kamińska and Magdalena Krajewska},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2018},
  volume={34 4},
  pages={
          587-596
        }
}
  • R. CoppoL. Peruzzi M. Krajewska
  • Published 9 April 2018
  • Medicine, Biology
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND Complement is thought to play a role in immunoglobulin A nephropathy (IgAN), though the activating mechanisms are unknown. This study focused on the gene expression of CD46 and CD55, two key molecules for regulating C3 convertase activity of lectin and alternative complement pathways at a cellular level. METHODS The transcriptional expression in peripheral white blood cells (WBCs) of CD46 and CD55 was investigated in 157 patients enrolled by the Validation of the Oxford… 

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