Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila.

@article{Jursnich1990DefectiveGC,
  title={Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila.},
  author={V A Jursnich and Scott E. Fraser and Lewis Irving Held and Jan Stephen Ryerse and Peter J. Bryant},
  journal={Developmental biology},
  year={1990},
  volume={140 2},
  pages={413-29}
}
The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations and one allele (dco3) when homozygous cause the imaginal discs to continue to grow beyond the normal disc-intrinsic limit during an extended larval period. Some degeneration also… CONTINUE READING