Defective forebrain development in mice lacking gp330/megalin.

@article{Willnow1996DefectiveFD,
  title={Defective forebrain development in mice lacking gp330/megalin.},
  author={Thomas E. Willnow and Jan Hilpert and Scott A. Armstrong and Astrid Rohlmann and Robert Hammer and Dennis K. Burns and Joachim Herz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 16},
  pages={
          8460-4
        }
}
gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules, such as cholesterol-carrying lipoproteins, proteases, and antiproteinases. Megalin knockout mice manifest abnormalities in epithelial tissues including lung and kidney that normally express the protein and they die perinatally from respiratory insufficiency… CONTINUE READING

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