Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

  title={Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia},
  author={Nicolas Baeyens and Bruno Larriv{\'e}e and Roxana Ola and Brielle Hayward-Piatkowskyi and Alexandre Dubrac and Billy Huang and Tyler D Ross and Brian G Coon and Elizabeth Min and Maya Tsarfati and Haibin Tong and A. R. Eichmann and Martin A Schwartz},
  booktitle={The Journal of cell biology},
Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations in Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 and 10. Evidence suggests that a second hit results in clonal expansion of endothelial cells to form lesions with… CONTINUE READING
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