Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells.

@article{Song2009DefectiveEO,
  title={Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells.},
  author={Ju Han Song and Seung Hyun Kim and Sin Ho Kweon and Tae Hyang Lee and Hee-Je Kim and Hyeoung-Joon Kim and Tae Sung Kim},
  journal={International journal of oncology},
  year={2009},
  volume={34 4},
  pages={1165-71}
}
Resistance to cytarabine (Ara-C) incapacitates the therapeutic effort during the treatment of acute myeloid leukemia (AML). To elucidate mechanism responsible for the development of resistance to Ara-C, we established the Ara-C resistant AML-2/WT cell sublines, AML-2/IDAC and AML-2/ARC. We then conducted DNA microarray analysis to compare the AML-2/IDAC cells with parental AML-2/WT cells. The results of the microarray analysis revealed a severe defect in the expression of deoxycytidine kinase… CONTINUE READING

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