Defective export of a periplasmic enzyme disrupts regulation of fatty acid synthesis.

@article{Cho1995DefectiveEO,
  title={Defective export of a periplasmic enzyme disrupts regulation of fatty acid synthesis.},
  author={Hyung Suck. Cho and John E. Cronan},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 9},
  pages={
          4216-9
        }
}
Escherichia coli thioesterase I (TesA) encoded by the tesA gene is located in the cellular periplasm. The tesA gene was modified by deletion of the leader sequence such that the mature enzyme was instead localized to the cellular cytosol. Production of thioesterase I in the cytosol results in striking changes in the pattern of E. coli lipid synthesis. In contrast to normal E. coli cells, cells producing cytosolic TesA synthesize large amounts of free fatty acid at all stages of growth. Moreover… CONTINUE READING
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