Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism.

@article{Subramanian1995DefectiveEO,
  title={Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism.},
  author={Gowri Subramanian and R A Leblanc and Richard C. Wardley and A. Oveta Fuller},
  journal={The Journal of general virology},
  year={1995},
  volume={76 ( Pt 9)},
  pages={2375-9}
}
We have determined if a defect at entry of the human pathogen herpes simplex virus type 1 (HSV-1) into cultured porcine cells extends to HSV-2 and if the poor susceptibility of porcine cells for these viruses is indicative of in vivo species tropism. HSV-1 replicates poorly in swine testis (ST) and other porcine cells which lack a functional non-heparan sulphate receptor(s) required for virus entry. By several criteria, ST cells resist infection by either HSV-1 or HSV-2. Infection can be… CONTINUE READING