Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin.

@article{Papageorghiou2008DefectiveET,
  title={Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin.},
  author={Aris T Papageorghiou and Federico Prefumo and Karin Leslie and David C. Gaze and Paul O. Collinson and Basky Thilaganathan},
  journal={Human reproduction},
  year={2008},
  volume={23 4},
  pages={803-6}
}
BACKGROUND Ischemia-modified albumin (IMA), a protein elevated in cardiac ischemia, is also increased to supra-physiological levels in early normal pregnancy. This finding supports the hypothesis that normal trophoblast development is stimulated by a hypoxic intrauterine environment. The aim of this study was to examine whether first trimester IMA levels are further elevated with defective trophoblast development. METHODS Prospective study of healthy women with singleton pregnancies… CONTINUE READING

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