Defective development of the thymus and immunological abnormalities in the neurological mouse mutation "staggerer".

@article{Trenkner1986DefectiveDO,
  title={Defective development of the thymus and immunological abnormalities in the neurological mouse mutation "staggerer".},
  author={Ekkhart Trenkner and Michael K. Hoffmann},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1986},
  volume={6 6},
  pages={1733-7}
}
The autosomal recessive mouse mutation "staggerer" (sg/sg), located on chromosome 9, has been recognized as a neurological mutant because of movement abnormalities and defective cerebellar development. We show here that the sg/sg mutation not only affects the development of the cerebellum, but also causes developmental and regulatory changes of the immune system: We observed, on gross inspection, a marked delay in the development of sg/sg thymus, generally enlarged lymph nodes, and undersized… CONTINUE READING
17 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Immunization of dissociated spleen cell cultures from normal mice

  • R. I. Mishell, R. W. Dutton
  • J. Exp. Med
  • 1967
Highly Influential
5 Excerpts

Linkage map of the mouse

  • T. H. Roderick, M. T. Davisson
  • In Handbook on Genetically Standardized Jaxmice,
  • 1982

Similar Papers

Loading similar papers…