Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice.

@article{Kwee1995DefectiveDO,
  title={Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice.},
  author={Lia Kwee and Harold Scott Baldwin and H M Shen and Colin Lawson Stewart and Clayton A. Buck and Mark A. Labow},
  journal={Development},
  year={1995},
  volume={121 2},
  pages={489-503}
}
VCAM-1 is a cytokine-inducible cell surface protein capable of mediating adhesion to leukocytes expressing alpha 4 integrins. Mice deficient in VCAM-1 expression were produced by targeted homologous recombination in ES cells. VCAM-1-deficient embryos were not viable and exhibited either of two distinct phenotypes. Approximately half of the embryos died before embryonic day 11.5 and exhibited a severe defect in placental development in which the allantois failed to fuse with the chorion. The… CONTINUE READING
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