Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.

Abstract

Phosphate reabsorption in the renal proximal tubule occurs mostly via the type IIa Na(+)-phosphate cotransporter (NaP(i)-IIa) in the brush border membrane (BBM). The activity and localization of NaP(i)-IIa are regulated, among other factors, by parathyroid hormone (PTH). NaP(i)-IIa interacts in vitro via its last three COOH-terminal amino acids with the PDZ… (More)

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@article{Capuano2007DefectiveCO, title={Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.}, author={Paola Capuano and Desa Bacic and Marcel Roos and Serge Mike Gisler and Gerti Stange and Juerg Biber and Brigitte Kaissling and Edward J. Weinman and Shirish S Shenolikar and Carsten A Wagner and Heini Murer}, journal={American journal of physiology. Cell physiology}, year={2007}, volume={292 2}, pages={C927-34} }