Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells.

@article{Katoh2005DefectiveCA,
  title={Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells.},
  author={Arthur A. Katoh and Takashi Yoshida and Yufuko Himeshima and Masayoshi Mishina and Tomoo Hirano},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 5},
  pages={
          1315-26
        }
}
The ionotropic glutamate receptor delta2 subunit (GluRdelta2) is selectively expressed in cerebellar Purkinje cells and is implicated in long-term depression, synaptic formation and elimination. To study the effect of GluRdelta2 deficiency on motor control, we measured the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) induced by sinusoidal rotation of the animal and/or the surrounding screen in two GluRdelta2 mutant mice: a GluRdelta2 knockout mouse (delta2-/-) and a lurcher… CONTINUE READING
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