Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome.

@article{Tsubota2001DefectiveCT,
  title={Defective cellular trafficking of lacrimal gland aquaporin-5 in Sj{\"o}gren's syndrome.},
  author={Kazuo Tsubota and Shu Hirai and L. S. King and Peter Agre and Naruhiro Ishida},
  journal={Lancet},
  year={2001},
  volume={357 9257},
  pages={688-9}
}
Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a… CONTINUE READING

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