Defective cardiac ryanodine receptor regulation during atrial fibrillation.

  title={Defective cardiac ryanodine receptor regulation during atrial fibrillation.},
  author={John A. Vest and Xander H T Wehrens and Steven R. Reiken and Stephan E. Lehnart and Dobromir Dobrev and Parag Chandra and Peter R Danilo and Ursula Ravens and Michael R. Rosen and Andrew Robert Marks},
  volume={111 16},
BACKGROUND Ca2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including atrial fibrillation (AF). Protein kinase A (PKA) hyperphosphorylation of the cardiac ryanodine receptor (RyR2) resulting in dissociation of the channel-stabilizing subunit calstabin2 (FK506-binding protein or FKBP12.6) causes SR Ca2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2… CONTINUE READING