Defective carbohydrate metabolism in mice homozygous for the tubby mutation.

@article{Wang2006DefectiveCM,
  title={Defective carbohydrate metabolism in mice homozygous for the tubby mutation.},
  author={Yun Wang and Kevin L Seburn and Lawrence Bechtel and Bruce Y. Lee and Jin P. Szatkiewicz and Patsy M. Nishina and J{\"u}rgen K Naggert},
  journal={Physiological genomics},
  year={2006},
  volume={27 2},
  pages={131-40}
}
Tub is a member of a small gene family, the tubby-like proteins (TULPs), with predominant expression in neurons. Mice carrying a mutation in Tub develop retinal and cochlear degeneration as well as late-onset obesity with insulin resistance. During behavioral and metabolic testing, we found that homozygous C57BL/6J-Tub(tub) mice have a lower respiratory quotient than C57BL/6J controls before the onset of obesity, indicating that tubby homozygotes fail to activate carbohydrate metabolism and… CONTINUE READING