Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling.

@article{Zhang2013DefectiveAT,
  title={Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling.},
  author={Kai Rui Zhang and Rotem Fishel Ben Kenan and Yasuko Osakada and Wei Xu and Rachel S Sinit and Liang Chen and Xiaobei Zhao and Jia-Yun Chen and Bianxiao Cui and Chengbiao Wu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 17},
  pages={7451-62}
}
Retrograde trophic signaling of nerve growth factor (NGF) supports neuronal survival and differentiation. Dysregulated trophic signaling could lead to various neurological disorders. Charcot-Marie-Tooth type 2B (CMT2B) is one of the most common inherited peripheral neuropathies characterized by severe terminal axonal loss. Genetic analysis of human CMT2B patients has revealed four missense point mutations in Rab7, a small GTPase that regulates late endosomal/lysosomal pathways, but the exact… CONTINUE READING
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