Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA.

@article{Regan2006DefectiveAO,
  title={Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA.},
  author={John F Regan and Yuying Liang and Tristram G. Parslow},
  journal={Journal of virology},
  year={2006},
  volume={80 1},
  pages={252-61}
}
The RNA-dependent RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments (vRNAs) through intermediates known as cRNAs. Here we describe functional characterization of 16 site-directed mutants of one polymerase subunit, termed PA. In accord with earlier studies, these mutants exhibited diverse, mainly quantitative impairments in expressing one or more classes of viral RNA, with associated… CONTINUE READING

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