Defective antigen-presenting cell function in human neonates.

  title={Defective antigen-presenting cell function in human neonates.},
  author={P A Velilla and Mar{\'i}a Teresa Rugeles and Claire A. Chougnet},
  journal={Clinical immunology},
  volume={121 3},
Immaturity of the immune system has been suggested as an underlying factor for the high rate of morbidity and mortality from infections in newborns. Functional impairment of neonatal T cells is frequently quoted as the main underlying mechanism for such immaturity. However, recent studies suggest that neonatal antigen-presenting cells (APCs) also exhibit functional alterations, which could lead to secondary defects of adaptive T-cell responses. In this review, we summarize what is known on the… CONTINUE READING


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