Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma

@article{Strickland2012DefectiveAS,
  title={Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma},
  author={D. H. Strickland and J. Thomas and D. Mok and F. Blank and Kl L. McKenna and A. Larcombe and P. Sly and Patric G. Holt},
  journal={Mucosal Immunology},
  year={2012},
  volume={5},
  pages={332-341}
}
  • D. H. Strickland, J. Thomas, +5 authors Patric G. Holt
  • Published 2012
  • Biology, Medicine
  • Mucosal Immunology
  • A hallmark of atopic asthma is development of chronic airways hyper-responsiveness (AHR) that persists in the face of ongoing exposure to perennial aeroallergens. We investigated underlying mechanisms in sensitized rats focusing on a strain expressing the high-allergen–responder phenotype characteristic of human atopic asthmatics, and find that their high susceptibility to aeroallergen-induced persistent AHR is associated with deficiencies in the immunoregulatory and mucosal trafficking… CONTINUE READING
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