Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.

@article{Jin2004DefectiveAN,
  title={Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.},
  author={Kunlin Jin and Lin Xie and Sun Hee Kim and Sophie Parmentier-Batteur and Yunjuan Sun and Xiao Ou Mao and Jocelyn T Childs and David A. Greenberg},
  journal={Molecular pharmacology},
  year={2004},
  volume={66 2},
  pages={
          204-8
        }
}
Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogenesis in the adult brain. To investigate this possibility, we measured neurogenesis by intraperitoneal injection of bromodeoxyuridine (BrdU), which labels newborn neurons, in wild-type and CB1R-knockout (CB1R-KO) mice. CB1R-KO mice showed reductions in the number of BrdU-labeled cells to approximately 50% of wild-type (WT) levels in dentate gyrus and subventricular zone (SVZ), suggesting that CB1R… Expand
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