Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice.

@article{Sugiyama1997DefectiveAV,
  title={Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice.},
  author={Akihiko Sugiyama and Shinzaburou Hattori and Shigeo Tanaka and Fumiko Isoda and Steven P. Kleopoulos and Moshe Rosenfeld and M Kaplitt and Hisahiko Sekihara and C Mobbs},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={1997},
  volume={29 12},
  pages={599-603}
}
The present study assessed the feasibility of transferring the insulin gene into liver cells of diabetic individuals using a defective adenoassociated viral (AAV) vehicle. AAV offers several advantages over other viral vectors, since this vehicle can facilitate transfection in vivo without cell division and without any viral coding sequences (thus minimizing inflammation). The rat insulin gene and lacZ were each packed into a defective AAV vehicle (AAV-INS and AAV-lacZ, respectively… CONTINUE READING
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