• DOI:10.1016/S0140-6736(06)68265-2
Corpus ID: 13898663

Defective acute inflammation in Crohn's disease: a clinical investigation

@article{Marks2006DefectiveAI,
  title={Defective acute inflammation in Crohn's disease: a clinical investigation},
  author={D. Marks and M. Harbord and R. Macallister and F. Rahman and Jodi Young and B. Al-Lazikani and William D. Lees and M. Novelli and S. Bloom and A. Segal},
  journal={The Lancet},
  year={2006},
  volume={367},
  pages={668-678}
}

• D. Marks, M. Harbord, +7 authors A. Segal
• Published 2006
• Medicine
• The Lancet

BACKGROUND The cause of Crohn's disease has not been mechanistically proven. [...] Key MethodFINDINGS In patients with Crohn's disease, trauma to rectum, ileum, or skin led to abnormally low neutrophil accumulation (differences from healthy individuals of 79%, n=8, p=0.0003; 57%, n=3, p=0.05; 50%, n=13, p<0.0001, respectively) and lower production of proinflammatory interleukin 8 (63%, n=7, p=0.003; 63%, n=3, p=0.05; 45%, n=8, p<0.0001) and interleukin 1beta (50%, n=8, p=0.0005). Interleukin 8 secretion by…Expand

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