Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.

@article{Merion1983DefectiveAO,
  title={Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.},
  author={Michael Merion and Paul S. Schlesinger and Robert M. Brooks and Joan M. Moehring and Thomas J. Moehring and William S. Sly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 17},
  pages={
          5315-9
        }
}
Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this report, we present evidence that one class of mutants of Chinese hamster ovary (CHO)-K1 cells, which is "cross-resistant" to Pseudomonas exotoxin A, diphtheria toxin, and several… CONTINUE READING
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